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YPR194C / OPT2



Section 1: Phenotypes.
Gene-drug relationships for YPR194C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPR194C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for OPT2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
lapachol 500 uM 7.75605 2.9683e-10
ketoconazole 11.8 uM 7.11751 1.2202e-06
nacl 700 mM 5.09599 7.5159e-06
fk506 0.1 ug/ml 4.91884 1.2578e-05
prazosin hydrochloride 1000 uM 4.24352 5.1315e-05
fk506 0.1 ug/ml 4.1946 0.00010106
methotrexate 250 uM 4.02688 0.00010236
cantharidin 200 uM 3.75474 0.00034694
beclomethasone dipropionate 1000 uM 3.60069 0.00038109
23 degrees C 0 3.41239 0.0017828

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for OPT2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mitomycin c 1000 uM 7.31197 9.0251e-09
synthetic complete for BY4743 0 5.51122 0.0058813
fk506 0.1 ug/ml 5.29498 3.5557e-06
mitomycin c 1000 uM 4.47251 6.763e-05
zncl2 1875 uM 4.40091 5.0614e-05
mncl2 1 mM 4.2107 8.8156e-05
methotrexate 250 uM 4.20065 0.00013829
licl 150 mM 4.11595 0.00011598
ph4 8 3.90085 0.00021493
ph4 8 3.89277 0.00021992

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPR194C

Top 10 functional gene interactors with YPR194C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with OPT2 by heterozygous co-sensitivity:

Query Interactor Correlation
OPT2 IRC6 0.56965
OPT2 GDB1 0.5504
OPT2 YNL203C 0.52493
OPT2 YPR196W 0.5189
OPT2 SKI3 0.51275
OPT2 BNA6 0.50809
OPT2 ISC10 0.50169
OPT2 RDS1 0.50076
OPT2 FAR3 0.49973
OPT2 SHE2 0.49594

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with OPT2 by homozygous co-sensitivity:

Query Interactor Correlation
OPT2 YCR100C 0.73843
OPT2 LAP4 0.72327
OPT2 YCR099C 0.70466
OPT2 ADH6 0.69673
OPT2 HPA2 0.69616
OPT2 YIR043C 0.68014
OPT2 YPR147C 0.67949
OPT2 SOL1 0.67665
OPT2 YOR225W 0.67437
OPT2 GND2 0.65054

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:




External information about YPR194C

Other databases:

Visit YPR194C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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