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Yeast Fitness
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YPR188C / MLC2



Section 1: Phenotypes.
Gene-drug relationships for YPR188C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPR188C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MLC2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
benomyl 13.8 uM 2.24903 0.037184
benomyl 6.9 uM 2.22493 0.038326
lapachol 500 uM 2.22043 0.015624
bithionol 75 uM 2.19322 0.016637
nocodazole 6.9 uM 2.16813 0.041169
bithionol 75 uM 2.05937 0.022511
miconazole 50 nM 1.95074 0.034414
alverine citrate 500 uM 1.90416 0.040569
miconazole 50 nM 1.89861 0.040961
miconazole 50 nM 1.86111 0.043698

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MLC2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 9.74996 1.1111e-11
synthetic complete for BY4743 0 8.41068 0.00054694
synthetic complete for BY4743 0 6.18207 0.0017393
papuamide b 1 ug/ml 6.0613 3.5859e-07
synthetic complete for BY4743 0 4.90199 0.00031064
5-fluorouracil 19.2 uM 3.89849 0.0014842
papuamide b 0.7 ug/ml 3.61237 0.00048407
ph4 8 2.96655 0.0027392
ph4 8 2.82776 0.0039007
synthetic complete for BY4743 0 2.81648 0.0091353

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPR188C

Top 10 functional gene interactors with YPR188C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MLC2 by heterozygous co-sensitivity:

Query Interactor Correlation
MLC2 COY1 0.71858
MLC2 ADH7 0.67434
MLC2 RPL22B 0.64162
MLC2 DCW1 0.63922
MLC2 YKR012C 0.63053
MLC2 AMA1 0.60972
MLC2 SHE2 0.60427
MLC2 YFR056C 0.60417
MLC2 YDR541C 0.60342
MLC2 DMC1 0.59484

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with MLC2 by homozygous co-sensitivity:

Query Interactor Correlation
MLC2 YLR283W 0.71093
MLC2 YNK1 0.69413
MLC2 YLR271W 0.6762
MLC2 YCR100C 0.65925
MLC2 HSP12 0.65493
MLC2 YOR225W 0.64778
MLC2 YJR146W 0.64776
MLC2 DCS2 0.64571
MLC2 STB3 0.64335
MLC2 MLP1 0.63855

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YPR188C

Other databases:

Visit YPR188C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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