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Yeast Fitness
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YPR184W / GDB1



Section 1: Phenotypes.
Gene-drug relationships for YPR184W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPR184W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GDB1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nacl 700 mM 8.52013 4.8883e-10
dihydromotuporamine C 15 uM 8.26433 9.6432e-10
methotrexate 125 uM 6.60616 9.4992e-08
nacl 700 mM 4.75482 2.0235e-05
methotrexate 250 uM 4.16123 6.6809e-05
methotrexate 250 uM 4.14563 7.0222e-05
nacl 700 mM 3.96636 0.00019246
filipin 100 uM 3.48769 0.00071992
5-fluorouracil 19.2 uM 3.43589 0.00082776
dimethylellipticinium 100 uM 3.34466 0.0010566

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GDB1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mncl2 2 mM 14.9483 < 1e-12
mitomycin c 1000 uM 14.1768 < 1e-12
rapamycin 6 nM 7.75757 2.5148e-09
alverine citrate 500 uM 7.65482 2.0019e-08
synthetic complete for BY4743 0 5.40955 0.0061937
mncl2 1 mM 5.00607 8.4348e-06
mechlorethamine 62.5 uM 4.96664 1.8348e-05
clotrimazole 2 uM 4.80851 2.7856e-05
37 degrees C 0 4.66089 4.1137e-05
mitomycin c 1000 uM 4.47656 6.6911e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPR184W

Top 10 functional gene interactors with YPR184W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with GDB1 by heterozygous co-sensitivity:

Query Interactor Correlation
GDB1 TOS2 0.66372
GDB1 ATG13 0.66146
GDB1 SKI3 0.64875
GDB1 SHE2 0.64101
GDB1 BSP1 0.62291
GDB1 FAR3 0.58867
GDB1 YGR001C 0.58758
GDB1 YKR012C 0.58591
GDB1 YKL187C 0.58512
GDB1 YKL131W 0.58458

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with GDB1 by homozygous co-sensitivity:

Query Interactor Correlation
GDB1 TRF5 0.61161
GDB1 HXT4 0.59712
GDB1 YHI9 0.56424
GDB1 YHR087W 0.54403
GDB1 NCL1 0.53874
GDB1 DMA2 0.53614
GDB1 GRH1 0.53117
GDB1 FAR10 0.51801
GDB1 SLK19 0.51714
GDB1 YPT52 0.50815

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None




External information about YPR184W

Other databases:

Visit YPR184W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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