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Yeast Fitness
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YPR167C / MET16



Section 1: Phenotypes.
Gene-drug relationships for YPR167C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPR167C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MET16 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
itraconazole 4.4 uM 6.1057 9.3099e-08
benomyl 13.8 uM 2.77153 0.019647
5-fluorouracil 76.9 uM 2.71804 0.0045838
nimustine 1000 uM 2.51929 0.0076092
benomyl 6.9 uM 2.46213 0.02854
itraconazole 8.8 uM 2.39978 0.01021
itraconazole 35.4 uM 2.38429 0.0106
cocl2 1250 uM 2.32712 0.013223
aklavin hydrochloride 125 uM 2.24283 0.014831
dmso 4% 4 uM 2.21457 0.015837

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MET16 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 55.231 1.8402e-08
synthetic complete for BY4743 0 44.994 5.1194e-08
synthetic complete for BY4743 0 24.0925 1.1479e-06
synthetic complete for BY4743 0 21.2122 2.158e-06
synthetic complete for BY4743 0 19.7815 1.0543e-07
minimal media 0 14.697 < 1e-12
synthetic complete for BY4743 0 13.5031 1.4348e-06
minimal media 0 12.8331 7.7512e-08
carboplatin 15 mM 10.3992 2.4369e-09
synthetic complete for BY4743 0 6.86462 0.00011941

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPR167C

Top 10 functional gene interactors with YPR167C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MET16 by heterozygous co-sensitivity:

Query Interactor Correlation
MET16 SHE2 0.68373
MET16 RNH1 0.62941
MET16 YKR047W 0.61318
MET16 DCW1 0.61006
MET16 YGR011W 0.60221
MET16 COY1 0.60215
MET16 YKL151C 0.59805
MET16 YKL070W 0.59631
MET16 YKL105C 0.59503
MET16 ADE17 0.59125

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with MET16 by homozygous co-sensitivity:

Query Interactor Correlation
MET16 CPA2 0.50311
MET16 YNL235C 0.47316
MET16 SER1 0.46974
MET16 SHM2 0.45605
MET16 NOT3 0.45525
MET16 NUT1 0.44916
MET16 YAL061W 0.44001
MET16 YOR379C 0.43307
MET16 GDH1 0.43195
MET16 PTP2 0.43102

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YPR167C

Other databases:

Visit YPR167C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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