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Yeast Fitness

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YPR162C / ORC4

Section 1: Phenotypes.
Gene-drug relationships for YPR162C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPR162C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ORC4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 6.77486 0.00053258
dna protein kinase inhibitor 0 5.7678 1.064e-06
latrunculin 1.95 uM 3.62581 0.00049455
latrunculin 3.91 uM 3.39005 0.00093602
ID 693632 62.5 uM 3.31938 0.00113
dihydromotuporamine C 15 uM 3.15409 0.0017455
papuamide b 0.37 ug/ml 3.12581 0.0018787
ID 621889 125 uM 3.03739 0.0023603
distamycin a 250 uM 2.953 0.0029273
allyl sulfide 0.12 % 2.89764 0.0033667

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YPR162C

Top 10 functional gene interactors with YPR162C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with ORC4 by heterozygous co-sensitivity:

Query Interactor Correlation
ORC4 SNC2 0.43491
ORC4 CBP6 0.34851
ORC4 YOR314W 0.34725
ORC4 GLN4 0.34689
ORC4 RSM18 0.33335
ORC4 CDC54 0.32713
ORC4 YMR098C 0.32411
ORC4 ACP1 0.32242
ORC4 SNO3 0.32024
ORC4 SME1 0.32022

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YPR162C

Other databases:

Visit YPR162C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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