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YPR159W / KRE6



Section 1: Phenotypes.
Gene-drug relationships for YPR159W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPR159W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for KRE6 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 5.12572 0.0018447
dna protein kinase inhibitor 0 4.8475 1.547e-05
methotrexate 250 uM 2.85038 0.0032325
amphotericin b 10 uM 2.84085 0.0033159
distamycin a 250 uM 2.61279 0.0067839
bay 11-7082 12.5 uM 2.50191 0.0088291
ansamitosin 500 uM 2.47879 0.0093214
no drug minimal media 0 2.41627 0.030197
methotrexate 250 uM 2.41348 0.009876
no drug minimal media 0 2.33585 0.033362

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for KRE6 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
papuamide b 0.7 ug/ml 5.94738 6.2773e-06
latrunculin 0.78 uM 5.84714 7.718e-06
potassium disulfite 2500 uM 5.70226 1.0427e-05
ph4 7.5 4.83602 6.6281e-05
2-cyanoethyl acrylate 360000 uM 4.21972 0.00025758
synthetic complete for BY4743 0 4.10051 0.0022851
licl 100 mM 4.03386 0.00038941
ph4 7.5 4.004 0.00041619
latrunculin 0.78 uM 3.00596 0.04757
rapamycin 9 nM 2.90742 0.05037

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPR159W

Top 10 functional gene interactors with YPR159W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with KRE6 by heterozygous co-sensitivity:

Query Interactor Correlation
KRE6 BRF1 0.49646
KRE6 ARO2 0.43125
KRE6 SFT1 0.42938
KRE6 PCP1 0.41403
KRE6 CKB1 0.40831
KRE6 YGL102C 0.39873
KRE6 GET1 0.39727
KRE6 NSA1 0.38971
KRE6 COG2 0.38819
KRE6 NBP35 0.37786

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YPR159W

Other databases:

Visit YPR159W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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