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YPR133W-A / TOM5



Section 1: Phenotypes.
Gene-drug relationships for YPR133W-A
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPR133W-A deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TOM5 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 100 uM 5.7906 2.7881e-07
fk506 0.1 ug/ml 5.32545 3.8539e-06
licl 150 mM 4.97193 1.078e-05
tomatine 62.5 uM 4.58545 1.6823e-05
nacl 700 mM 4.57893 3.3633e-05
fk506 0.1 ug/ml 4.24393 8.7832e-05
nacl 700 mM 4.06715 0.00014495
mechlorethamine 500 uM 3.33213 0.00084283
caspofungin 10 nM 3.30459 0.00091276
37 degrees C 0 3.16002 0.0013794

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for TOM5 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 50.541 < 1e-12
mms 0.002 % 41.6572 0.00028788
latrunculin 0.78 uM 24.3204 0.0008432
licl 100 mM 23.5134 < 1e-12
latrunculin 0.78 uM 18.077 0.0015231
bleomycin 1.13 ug/ml 9.23999 1.4857e-08
bleomycin 1.13 ug/ml 8.25772 7.7783e-08
bleomycin 1.7 ug/ml 8.24768 7.9159e-08
latrunculin 3 uM 7.53912 2.8228e-07
bleomycin 1.7 ug/ml 7.52783 2.8821e-07

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPR133W-A

Top 10 functional gene interactors with YPR133W-A. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with TOM5 by heterozygous co-sensitivity:

Query Interactor Correlation
TOM5 CPR7 0.74383
TOM5 PGA3 0.71417
TOM5 USO1 0.70694
TOM5 ECM16 0.69347
TOM5 YJL032W 0.68672
TOM5 MET4 0.68012
TOM5 POL12 0.67781
TOM5 MED11 0.67679
TOM5 SNT309 0.67662
TOM5 YAR1 0.6761

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YPR133W-A

Other databases:

Visit YPR133W-A in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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