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Yeast Fitness

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YPR110C / RPC40

Section 1: Phenotypes.
Gene-drug relationships for YPR110C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPR110C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPC40 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 22.2753 0.0010046
cantharidin 250 uM 8.42897 0.0068924
cantharidin 250 uM 7.96377 0.0077021
cantharidin 250 uM 7.53267 0.0085856
cantharidin 250 uM 7.34764 0.0090117
cantharidin 250 uM 6.72258 0.010709
cantharidin 250 uM 6.66101 0.010902
alverine citrate 500 uM 4.97727 0.019038
methotrexate 500 uM 4.75971 1.9951e-05
dihydromotuporamine C 15 uM 4.45707 4.7754e-05

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YPR110C

Top 10 functional gene interactors with YPR110C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with RPC40 by heterozygous co-sensitivity:

Query Interactor Correlation
RPC40 COG4 0.60882
RPC40 SSY1 0.56424
RPC40 SMP3 0.56366
RPC40 RMD9 0.56316
RPC40 RAI1 0.55991
RPC40 MRD1 0.55774
RPC40 NAR1 0.551
RPC40 MER1 0.54727
RPC40 SGF73 0.5446
RPC40 RRN3 0.54106

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YPR110C

Other databases:

Visit YPR110C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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