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Yeast Fitness

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YPR035W / GLN1

Section 1: Phenotypes.
Gene-drug relationships for YPR035W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPR035W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GLN1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
daunorubicin 125 uM 4.46729 2.4812e-05
tryptanthrin 250 uM 3.43796 0.00082316
5-fluorocytosine 15.6 uM 2.89753 0.0028481
5-fluorocytosine 15.6 uM 2.74084 0.0043189
osajin 1000 uM 2.63829 0.0056323
fluconazole 130.6 uM 2.62766 0.0057875
miconazole 100 uM 2.50708 0.0078442
haloperidol 125 uM 2.41618 0.0098112
methotrexate 500 uM 2.36138 0.01223
dihydromotuporamine C 7.5 uM 2.32589 0.01326

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YPR035W

Top 10 functional gene interactors with YPR035W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with GLN1 by heterozygous co-sensitivity:

Query Interactor Correlation
GLN1 HES1 0.52092
GLN1 APC5 0.51493
GLN1 LEA1 0.49045
GLN1 RRP1 0.48946
GLN1 FAD1 0.48323
GLN1 VRP1 0.46096
GLN1 KAE1 0.46001
GLN1 ATG11 0.45536
GLN1 TPT1 0.45413
GLN1 YDL032W 0.45353

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YPR035W

Other databases:

Visit YPR035W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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