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YPR014C / YPR014C



Section 1: Phenotypes.
Gene-drug relationships for YPR014C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPR014C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YPR014C Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 7.06172 0.00044021
no drug minimal media 0 6.88383 0.00049502
methotrexate 500 uM 6.68934 7.4948e-08
no drug minimal media 0 4.99109 0.0020681
latrunculin 6.25 uM 4.46944 0.00019364
no drug minimal media 0 4.37814 0.0035835
no drug minimal media 0 4.36838 0.0036165
tryptanthrin 250 uM 3.96001 0.00019591
no drug minimal media 0 3.94138 0.0038063
5-fluorouracil 38.4 uM 3.76925 0.00033329

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YPR014C Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 11.0208 5.3536e-05
synthetic complete for BY4743 0 10.941 5.5447e-05
wiskostatin 29 uM 10.6485 < 1e-12
synthetic complete for BY4743 0 6.71729 0.0012787
synthetic complete for BY4743 0 5.5097 0.0026472
mncl2 2 mM 5.1895 4.8756e-06
synthetic complete for BY4743 0 4.77269 0.0010147
synthetic complete for BY4743 0 4.30737 0.0038308
synthetic complete for BY4743 0 4.19382 0.0020333
synthetic complete for BY4743 0 3.92555 0.0055599

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPR014C

Top 10 functional gene interactors with YPR014C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YPR014C by heterozygous co-sensitivity:

Query Interactor Correlation
YPR014C YJL067W 0.58488
YPR014C YCR102W-A 0.58285
YPR014C YHR113W 0.5795
YPR014C PHO8 0.56241
YPR014C RDR1 0.52865
YPR014C YSP2 0.51488
YPR014C YPR053C 0.50459
YPR014C ATG12 0.49315
YPR014C BZZ1 0.49194
YPR014C YIL092W 0.48693

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YPR014C by homozygous co-sensitivity:

Query Interactor Correlation
YPR014C FSH1 0.82188
YPR014C RNP1 0.80795
YPR014C AVT7 0.79771
YPR014C GAS5 0.78741
YPR014C AHT1 0.78388
YPR014C FMS1 0.77873
YPR014C YOL029C 0.7787
YPR014C SPH1 0.7742
YPR014C YHR126C 0.77357
YPR014C DBP1 0.76991

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YPR014C

Other databases:

Visit YPR014C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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