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Yeast Fitness
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YPR009W / SUT2



Section 1: Phenotypes.
Gene-drug relationships for YPR009W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPR009W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SUT2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 6.25 uM 4.49437 0.0001839
cantharidin 250 uM 3.87516 0.030301
nacl 700 mM 3.83808 0.00027537
sodium sulfate 625 uM 3.10505 0.0019826
dmso 4% 4 uM 3.06965 0.0017771
5-fluorouracil 76.9 uM 2.49179 0.0081477
emodin 250 uM 2.31308 0.012572
parthenolide 125 uM 2.30496 0.012816
miconazole 50 nM 2.144 0.02387
itraconazole 17.7 uM 2.13232 0.019118

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SUT2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 10 ug/ml 9.47314 1.0203e-08
cadmium chloride 7.81 uM 7.88498 1.7521e-09
nocodazole 10 ug/ml 7.37797 3.8045e-07
latrunculin 0.78 uM 6.77918 0.010537
mms 0.002 % 5.32249 0.016767
latrunculin 0.78 uM 4.90756 0.019551
mitomycin c 1000 uM 4.65644 2.3847e-05
psoralen 0.5 uM 3.72694 0.00077162
synthetic complete for BY4743 0 3.51475 0.036141
isoleucine dropout 0 3.45095 0.0015259

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPR009W

Top 10 functional gene interactors with YPR009W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SUT2 by heterozygous co-sensitivity:

Query Interactor Correlation
SUT2 YOR300W 0.64643
SUT2 YPR015C 0.57804
SUT2 YGL217C 0.54783
SUT2 YCL023C 0.536
SUT2 COY1 0.53519
SUT2 ADE17 0.52927
SUT2 YHR130C 0.51334
SUT2 YDR537C 0.50787
SUT2 LAT1 0.50723
SUT2 YNR063W 0.5031

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SUT2 by homozygous co-sensitivity:

Query Interactor Correlation
SUT2 YPR071W 0.63361
SUT2 YJL067W 0.61128
SUT2 RDI1 0.60969
SUT2 RIF2 0.59319
SUT2 PRM10 0.5719
SUT2 TOS8 0.54908
SUT2 DSS4 0.54786
SUT2 CRN1 0.54695
SUT2 RCK1 0.54067
SUT2 FRE4 0.5396

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:




External information about YPR009W

Other databases:

Visit YPR009W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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