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Yeast Fitness
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YPR008W / HAA1



Section 1: Phenotypes.
Gene-drug relationships for YPR008W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPR008W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for HAA1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
clotrimazole 1 uM 6.20363 6.6146e-08
fluconazole 65.3 uM 4.43848 2.7265e-05
caspofungin 10 nM 4.38626 3.2327e-05
caspofungin 10 nM 4.18539 6.184e-05
trichlormethine 1000 uM 3.70814 0.00027523
drofenine hydrochloride 750 uM 3.31221 0.00089288
alverine citrate 500 uM 3.23241 0.0035936
caspofungin 10 nM 3.01287 0.0020796
miconazole 0.2 uM 2.78828 0.0038126
aklavin hydrochloride 500 uM 2.76201 0.0040858

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for HAA1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
lysine dropout 0 3.64997 0.00099091
isoleucine dropout 0 3.64002 0.0010125
threonine dropout 0 3.61351 0.0010725
threonine dropout 0 3.58143 0.0011499
synthetic complete for BY4743 0 3.4962 0.0028815
synthetic complete for BY4743 0 3.41569 0.001647
synthetic complete for BY4743 400 uM 3.37506 0.0017984
synthetic complete for BY4743 0 3.2664 0.0022741
synthetic complete for BY4743 0 3.07979 0.01847
tyrosine dropout 0 3.044 0.0036663

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPR008W

Top 10 functional gene interactors with YPR008W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with HAA1 by heterozygous co-sensitivity:

Query Interactor Correlation
HAA1 LAT1 0.58058
HAA1 NIT3 0.56165
HAA1 ITT1 0.54837
HAA1 YKL215C 0.50512
HAA1 RIF2 0.5007
HAA1 CSR2 0.49426
HAA1 FKH2 0.49357
HAA1 CAR2 0.48714
HAA1 YMR141C 0.48668
HAA1 YGR025W 0.48259

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with HAA1 by homozygous co-sensitivity:

Query Interactor Correlation
HAA1 XPT1 0.77299
HAA1 RPL22B 0.75581
HAA1 ITT1 0.73193
HAA1 YGR025W 0.72485
HAA1 FRE2 0.72435
HAA1 YOR131C 0.71618
HAA1 YKL066W 0.68936
HAA1 YOR220W 0.68851
HAA1 YPR126C 0.68211
HAA1 YMR147W 0.67896

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YPR008W

Other databases:

Visit YPR008W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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