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YPL248C / GAL4



Section 1: Phenotypes.
Gene-drug relationships for YPL248C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPL248C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GAL4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 6.25 uM 6.33654 4.9405e-06
progesterone 250 uM 5.06821 3.3385e-06
itraconazole 4.4 uM 4.76129 9.3817e-06
fluconazole 130.6 uM 4.49588 2.2592e-05
fk506 0.05 ug/ml 4.34505 6.5823e-05
cantharidin 250 uM 4.0223 0.028306
itraconazole 17.7 uM 3.80574 0.00020405
itraconazole 17.7 uM 3.20359 0.0012192
5-fluorouracil 38.5 uM 3.03429 0.0019602
no drug minimal media 0 2.89846 0.016926

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GAL4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
yp glycerol 0 17.9517 3.0773e-09
yp glycerol 0 12.2583 1.1953e-07
rapamycin 9 nM 11.2049 0.00076191
yp glycerol 0 8.40853 9.2029e-08
nocodazole 10 ug/ml 8.098 1.0298e-07
rapamycin 9 nM 7.42443 0.0088312
yp glycerol 0 7.17012 7.8401e-07
rapamycin 9 nM 5.38643 0.016391
myriocin 0.2 ug/ml 4.82188 6.8357e-05
zncl2 1875 uM 4.42926 4.6578e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPL248C

Top 10 functional gene interactors with YPL248C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with GAL4 by heterozygous co-sensitivity:

Query Interactor Correlation
GAL4 ECM34 0.62422
GAL4 ADE17 0.57777
GAL4 YMR306C-A 0.57714
GAL4 YMR135W-A 0.54469
GAL4 YER085C 0.53406
GAL4 RNH1 0.53129
GAL4 MET16 0.51567
GAL4 RCE1 0.51363
GAL4 YGL217C 0.511
GAL4 INP51 0.49276

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with GAL4 by homozygous co-sensitivity:

Query Interactor Correlation
GAL4 CPR2 0.63045
GAL4 YJL055W 0.60758
GAL4 PUF2 0.59694
GAL4 YPL229W 0.59068
GAL4 YMR320W 0.58513
GAL4 YMR244W 0.58215
GAL4 HAP5 0.5815
GAL4 ATE1 0.57126
GAL4 COS1 0.56727
GAL4 DBP1 0.55128

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YPL248C

Other databases:

Visit YPL248C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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