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Yeast Fitness
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YPL243W / SRP68



Section 1: Phenotypes.
Gene-drug relationships for YPL243W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPL243W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SRP68 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
anisomycin 62.5 uM 7.01559 3.8719e-09
itraconazole 17.7 uM 5.59403 5.5083e-07
methotrexate 500 uM 5.1151 2.8471e-06
itraconazole 17.7 uM 4.62288 1.4864e-05
bithionol 75 uM 4.47852 2.3915e-05
mechlorethamine 500 uM 4.47299 2.4353e-05
berberine chloride 125 uM 4.45619 2.573e-05
mechlorethamine 500 uM 4.45513 2.5819e-05
bithionol 75 uM 4.3088 4.1568e-05
bithionol 75 uM 4.17198 6.4552e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YPL243W

Top 10 functional gene interactors with YPL243W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SRP68 by heterozygous co-sensitivity:

Query Interactor Correlation
SRP68 HAS1 0.4264
SRP68 RRP3 0.41135
SRP68 HYS2 0.40538
SRP68 IRA1 0.40352
SRP68 SRV2 0.37784
SRP68 GPM1 0.37676
SRP68 YNL171C 0.36576
SRP68 POP3 0.35968
SRP68 SEC65 0.35909
SRP68 FMN1 0.35246

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YPL243W

Other databases:

Visit YPL243W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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