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Yeast Fitness
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YPL241C / CIN2



Section 1: Phenotypes.
Gene-drug relationships for YPL241C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPL241C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CIN2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
econazole nitrate 0.24 uM 7.6808 3.8454e-10
itraconazole 17.7 uM 6.2455 5.7146e-08
trichlormethine 1000 uM 4.74362 9.9516e-06
hydroxyurea 100000 uM 4.58025 1.7113e-05
mitomycin c 1000 uM 3.78934 0.00021462
itraconazole 17.7 uM 3.52469 0.00047847
methotrexate 250 uM 3.52325 0.00065388
thiabendazole 250 uM 3.41135 0.00066893
mechlorethamine 500 uM 3.39744 0.00069677
clotrimazole 1 uM 3.27912 0.0009823

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for CIN2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 13.4206 5.0671e-08
benomyl 10 ug/ml 11.272 6.8638e-10
nocodazole 10 ug/ml 11.2084 7.5082e-10
synthetic complete for BY4743 0 10.3659 5.7118e-07
nocodazole 10 ug/ml 9.7471 6.6135e-09
benomyl 10 ug/ml 9.70199 7.0987e-09
benomyl 10 ug/ml 9.69051 0.0011668
mebendazole 1000 uM 8.30125 4.3917e-09
potassium disulfite 2500 uM 8.16824 9.0989e-08
thiabendazole 250 uM 7.4423 3.3357e-08

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPL241C

Top 10 functional gene interactors with YPL241C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with CIN2 by heterozygous co-sensitivity:

Query Interactor Correlation
CIN2 YJL032W 0.54598
CIN2 CEM1 0.54182
CIN2 RIB4 0.53952
CIN2 YAR1 0.53439
CIN2 YOR060C 0.5336
CIN2 CUS1 0.53197
CIN2 CEF1 0.52885
CIN2 YMR293C 0.52024
CIN2 CDC11 0.51517
CIN2 TAM41 0.50612

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with CIN2 by homozygous co-sensitivity:

Query Interactor Correlation
CIN2 CIN1 0.63375
CIN2 PAC2 0.58517
CIN2 MAD2 0.43252
CIN2 MAD1 0.40534
CIN2 TUB3 0.39689
CIN2 HGH1 0.38951
CIN2 EFT2 0.34353
CIN2 MRH4 0.34201
CIN2 PFK26 0.33756
CIN2 COQ4 0.33734

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YPL241C

Other databases:

Visit YPL241C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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