Retrieving results for YPL220W, please wait...

Yeast Fitness
Database

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search

YPL220W / RPL1A



Section 1: Phenotypes.
Gene-drug relationships for YPL220W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPL220W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPL1A Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fluconazole 130.6 uM 4.16434 6.615e-05
clotrimazole 1 uM 3.82768 0.00019069
drofenine hydrochloride 750 uM 3.57042 0.00041735
helenine 250 uM 3.55615 0.00043557
thiabendazole 250 uM 3.30832 0.00090297
dyclonine 500 uM 3.1147 0.0015671
econazole nitrate 0.24 uM 2.69315 0.00489
thiabendazole 500 uM 2.6753 0.005121
dihydromotuporamine C 15 uM 2.5821 0.0073011
bufexamac 1000 uM 2.41318 0.0098831

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPL1A Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mitomycin c 1000 uM 6.48188 1.0264e-07
rapamycin 9 nM 6.41452 0.0038388
latrunculin 0.78 uM 5.5437 0.0057859
mncl2 2 mM 4.195 9.2264e-05
ph4 8 3.94746 0.00018818
rapamycin 9 nM 3.91817 0.029697
sorbitol 1.5e+06 uM 3.49237 0.0008647
ph4 8 3.31323 0.0010982
floxuridine 3.37 uM 3.2285 0.0016784
rapamycin 9 nM 3.15389 0.043767

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPL220W

Top 10 functional gene interactors with YPL220W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPL1A by heterozygous co-sensitivity:

Query Interactor Correlation
RPL1A YKU70 0.50913
RPL1A YMR135W-A 0.4877
RPL1A YPR096C 0.47054
RPL1A YNL105W 0.46808
RPL1A OMA1 0.46021
RPL1A BIT61 0.45722
RPL1A GUT1 0.44947
RPL1A YML084W 0.44526
RPL1A ZSP1 0.44429
RPL1A ECM34 0.44407

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RPL1A by homozygous co-sensitivity:

Query Interactor Correlation
RPL1A HPA3 0.63305
RPL1A LIN1 0.6226
RPL1A YJR015W 0.61666
RPL1A YLR415C 0.60337
RPL1A YHL012W 0.60156
RPL1A YBR259W 0.59885
RPL1A SIA1 0.57831
RPL1A YOR055W 0.57407
RPL1A YMR187C 0.57276
RPL1A YOR223W 0.56425

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YPL220W

Other databases:

Visit YPL220W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


Download a plain text version of this page.