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Yeast Fitness

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YPL175W / SPT14

Section 1: Phenotypes.
Gene-drug relationships for YPL175W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPL175W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SPT14 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 6.25 uM 7.15689 1.1396e-06
fluconazole 130.6 uM 4.44432 2.6749e-05
itraconazole 35.4 uM 4.1221 7.5691e-05
lapachol 1000 uM 4.11336 7.7824e-05
myriocin 0.15 ug/ml 4.04138 0.00015587
clotrimazole 1 uM 3.66145 0.0003172
miconazole 100 uM 3.50119 0.00051311
5-fluorocytosine 15.6 uM 3.36795 0.00075947
dyclonine 500 uM 3.31578 0.0030791
clofoctol 1000 uM 3.15086 0.0014156

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YPL175W

Top 10 functional gene interactors with YPL175W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with SPT14 by heterozygous co-sensitivity:

Query Interactor Correlation
SPT14 TMA23 0.56495
SPT14 PPA2 0.55771
SPT14 ATP11 0.54235
SPT14 YCR064C 0.54118
SPT14 BRL1 0.53269
SPT14 MRD1 0.53191
SPT14 SED5 0.53041
SPT14 RFA1 0.51642
SPT14 NPT1 0.51486
SPT14 PCM1 0.51208

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YPL175W

Other databases:

Visit YPL175W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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