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Yeast Fitness
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YPL154C / PEP4



Section 1: Phenotypes.
Gene-drug relationships for YPL154C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPL154C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PEP4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 21.5363 0.0010745
methotrexate 500 uM 10.2614 6.0065e-12
methotrexate 500 uM 9.54954 3.4583e-11
dmso 4% 4 uM 7.1611 2.3311e-09
tryptanthrin 250 uM 5.1334 6.7409e-06
wiskostatin 29 uM 5.05137 8.5576e-06
cantharidin 250 uM 4.76019 1.9924e-05
methotrexate 250 uM 3.89292 0.00023635
methotrexate 125 uM 3.76679 0.00033557
daunorubicin 125 uM 3.75828 0.00023611

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PEP4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
phosphatase inhibitor 3 uM 13.7997 < 1e-12
bisphenol s 100 uM 11.8952 2.5451e-12
cadmium chloride 7.81 uM 10.4332 < 1e-12
zncl2 1875 uM 9.05066 7.0354e-11
mncl2 2 mM 8.43908 3.7217e-10
bisphenol s 100 uM 8.29654 4.4396e-09
mms 0.002 % 8.22084 0.0072381
sodium sulfate 625 uM 6.43339 1.185e-07
mitomycin c 1000 uM 5.91905 1.5171e-06
phosphatase inhibitor 2 uM 5.37595 2.7899e-06

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPL154C

Top 10 functional gene interactors with YPL154C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with PEP4 by heterozygous co-sensitivity:

Query Interactor Correlation
PEP4 ZRC1 0.46134
PEP4 URA8 0.45805
PEP4 CSI2 0.45433
PEP4 YPL168W 0.45354
PEP4 YHR138C 0.44986
PEP4 SNZ2 0.43612
PEP4 DOG1 0.43388
PEP4 NSG1 0.4266
PEP4 PRY3 0.4245
PEP4 MUC1 0.42072

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with PEP4 by homozygous co-sensitivity:

Query Interactor Correlation
PEP4 PRB1 0.50315
PEP4 ERV25 0.50247
PEP4 YKL071W 0.47581
PEP4 TCB3 0.46901
PEP4 YKL137W 0.43501
PEP4 STE24 0.4285
PEP4 ADE17 0.4279
PEP4 YMR084W 0.42394
PEP4 YPR059C 0.42158
PEP4 FTR1 0.39782

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YPL154C

Other databases:

Visit YPL154C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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