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Yeast Fitness
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YPL126W / NAN1



Section 1: Phenotypes.
Gene-drug relationships for YPL126W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPL126W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for NAN1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 5.74697 1.1304e-06
itraconazole 17.7 uM 5.50445 7.5044e-07
cantharidin 250 uM 5.35359 0.016582
lovastatin 77.2 uM 5.34973 1.2776e-06
itraconazole 17.7 uM 4.72411 1.062e-05
fluconazole 130.6 uM 4.67644 1.2445e-05
methotrexate 250 uM 4.53339 3.8347e-05
cantharidin 250 uM 4.37964 5.9623e-05
licl 150 mM 4.252 8.5837e-05
fenpropimorph 8 nM 4.23556 5.2644e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YPL126W

Top 10 functional gene interactors with YPL126W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with NAN1 by heterozygous co-sensitivity:

Query Interactor Correlation
NAN1 SSE1 0.46479
NAN1 YJL086C 0.43793
NAN1 CEF1 0.4332
NAN1 AEP2 0.43085
NAN1 ARB1 0.42559
NAN1 YJL046W 0.42402
NAN1 UFD1 0.42357
NAN1 MRPL33 0.42147
NAN1 TAF7 0.41915
NAN1 ERG8 0.41561

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YPL126W

Other databases:

Visit YPL126W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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