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Yeast Fitness
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YPL084W / BRO1



Section 1: Phenotypes.
Gene-drug relationships for YPL084W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPL084W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for BRO1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
lovastatin 77.2 uM 17.4082 < 1e-12
cocl2 1250 uM 11.4532 < 1e-12
latrunculin 3.91 uM 9.99639 1.1436e-11
berberine chloride 125 uM 6.83593 7.2516e-09
methotrexate 250 uM 4.10796 0.00012917
methotrexate 500 uM 3.3996 0.00069237
tomatine 62.5 uM 3.36474 0.00076661
ro 106-9920 (Calbio) 125 uM 3.27467 0.0012721
thiabendazole 500 uM 3.00941 0.0020995
benztropine 1 uM 2.98394 0.0022516

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for BRO1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 145.365 2.366e-05
synthetic complete for BY4743 0 132.806 2.8346e-05
synthetic complete for BY4743 0 123.654 3.2697e-05
synthetic complete for BY4743 0 79.4118 3.0016e-09
synthetic complete for BY4743 0 75.0065 2.6114e-06
synthetic complete for BY4743 0 74.878 4.0258e-09
synthetic complete for BY4743 0 60.9397 4.3687e-11
synthetic complete for BY4743 0 52.6027 1.1919e-10
synthetic complete for BY4743 0 51.0743 2.7196e-08
synthetic complete for BY4743 0 46.0496 4.56e-08

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPL084W

Top 10 functional gene interactors with YPL084W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with BRO1 by heterozygous co-sensitivity:

Query Interactor Correlation
BRO1 DYN1 0.74809
BRO1 YIL067C 0.70692
BRO1 YKL187C 0.68972
BRO1 PGM1 0.6749
BRO1 ADE1 0.66778
BRO1 CWP1 0.66713
BRO1 YPT7 0.64835
BRO1 YKL083W 0.63553
BRO1 PRR1 0.63513
BRO1 TOS2 0.63057

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with BRO1 by homozygous co-sensitivity:

Query Interactor Correlation
BRO1 SRN2 0.80814
BRO1 MVB12 0.77894
BRO1 DID2 0.76362
BRO1 YNR005C 0.75022
BRO1 VPS24 0.73828
BRO1 VPS27 0.7224
BRO1 VPS4 0.70397
BRO1 OPI8 0.68826
BRO1 VPS60 0.68324
BRO1 DID4 0.66416

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None




External information about YPL084W

Other databases:

Visit YPL084W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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