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Yeast Fitness
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YPL018W / CTF19



Section 1: Phenotypes.
Gene-drug relationships for YPL018W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPL018W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CTF19 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dihydromotuporamine C 15 uM 12.6936 < 1e-12
dna protein kinase inhibitor 0 6.32977 2.0963e-07
alverine citrate 500 uM 5.41828 0.016208
dyclonine 500 uM 4.54727 1.908e-05
promazine hydrochloride 125 uM 4.17226 6.4494e-05
aminophenazone 250 uM 4.13155 7.3446e-05
methotrexate 125 uM 3.55674 0.00059706
semustine 125 uM 3.49626 0.00052068
sulfanilamide 62.5 uM 3.4644 0.0005722
ID 630688 250 uM 3.44324 0.00081155

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for CTF19 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 7.33796 0.0090349
rapamycin 9 nM 5.90249 0.013762
methotrexate 250 uM 4.26767 0.00011597
nocodazole 10 ug/ml 4.26548 0.0002327
amphotericin b 0.31 uM 4.1417 0.0001614
cisplatin 125 uM 4.10986 0.00017543
caspofungin 1 nM 4.01861 0.00022268
methotrexate 250 uM 3.98189 0.00024505
sorbitol 1.5e+06 uM 3.95249 0.0013596
sorbitol 1.5e+06 uM 3.74308 0.00080953

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YPL018W

Top 10 functional gene interactors with YPL018W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with CTF19 by heterozygous co-sensitivity:

Query Interactor Correlation
CTF19 MRP49 0.52161
CTF19 YGR016W 0.51784
CTF19 LDB7 0.50865
CTF19 YOR218C 0.50095
CTF19 YGL007W 0.48717
CTF19 LDB16 0.47456
CTF19 ARO2 0.46996
CTF19 NBP35 0.45275
CTF19 DST1 0.45199
CTF19 FMP38 0.44741

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with CTF19 by homozygous co-sensitivity:

Query Interactor Correlation
CTF19 HNT3 0.42518
CTF19 IRC4 0.4047
CTF19 PDX3 0.40279
CTF19 YNR004W 0.40149
CTF19 RPL24B 0.39975
CTF19 CBC2 0.396
CTF19 VPS72 0.38898
CTF19 RPL31B 0.38358
CTF19 MCM21 0.38011
CTF19 YBR053C 0.37853

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:




External information about YPL018W

Other databases:

Visit YPL018W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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