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Yeast Fitness

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YPL011C / TAF3

Section 1: Phenotypes.
Gene-drug relationships for YPL011C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YPL011C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TAF3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 9.61163 2.9607e-11
wiskostatin 29 uM 7.94392 2.2847e-09
latrunculin 1.95 uM 7.16994 1.9296e-08
methotrexate 250 uM 4.18874 0.00010275
methotrexate 500 uM 3.96215 0.00019474
methotrexate 500 uM 3.78721 0.00031712
resveratrol 2000 uM 3.41298 0.00088026
nitromide 1000 uM 3.22874 0.0011349
myriocin 0.15 ug/ml 3.07535 0.0021408
5-fluorouracil 38.4 uM 2.96928 0.0028087

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YPL011C

Top 10 functional gene interactors with YPL011C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with TAF3 by heterozygous co-sensitivity:

Query Interactor Correlation
TAF3 USE1 0.5344
TAF3 BUD13 0.50937
TAF3 SEC15 0.50909
TAF3 TFC7 0.49779
TAF3 CDC37 0.49059
TAF3 VPS66 0.48363
TAF3 YOR169C 0.48069
TAF3 TAF8 0.47519
TAF3 BTS1 0.46364
TAF3 YOR262W 0.4634

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YPL011C

Other databases:

Visit YPL011C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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