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Yeast Fitness
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YOR374W / ALD4



Section 1: Phenotypes.
Gene-drug relationships for YOR374W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOR374W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ALD4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
lapachol 500 uM 10.8249 < 1e-12
dna protein kinase inhibitor 0 7.05163 2.6893e-08
dihydromotuporamine C 15 uM 6.05092 4.6838e-07
methotrexate 500 uM 5.92586 6.727e-07
miconazole 0.2 uM 5.72156 1.5757e-05
methotrexate 500 uM 5.25823 4.687e-06
methotrexate 500 uM 4.54787 3.6782e-05
cloxyquin 15.6 uM 3.77405 0.00022495
sulconazole nitrate 0.24 uM 3.71393 0.00027041
alverine citrate 500 uM 3.64927 0.033784

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ALD4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 9.42054 0.0012673
hydroxyurea 100000 uM 5.73667 9.7059e-06
synthetic complete for BY4743 0 4.71998 0.021037
sorbitol 1.5e+06 uM 4.35294 0.00021639
synthetic complete for BY4743 0 3.79916 0.0063197
mncl2 2 mM 3.67816 0.00040294
sorbitol 1 M 3.56533 0.00055154
sorbitol 1.5e+06 uM 3.42008 0.0010384
mncl2 1 mM 3.2234 0.0013972
ph8 0 2.94405 0.0033694

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YOR374W

Top 10 functional gene interactors with YOR374W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ALD4 by heterozygous co-sensitivity:

Query Interactor Correlation
ALD4 YLR001C 0.5054
ALD4 PDR17 0.50003
ALD4 YJR038C 0.49236
ALD4 HXT10 0.49122
ALD4 YHR097C 0.49122
ALD4 YAR040C_d 0.48784
ALD4 ATG29 0.47152
ALD4 RIM4 0.46696
ALD4 YML116W-A 0.46541
ALD4 INP52 0.45461

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ALD4 by homozygous co-sensitivity:

Query Interactor Correlation
ALD4 HOS3 0.76418
ALD4 YML083C 0.724
ALD4 YAT1 0.719
ALD4 PSK1 0.71103
ALD4 DOT5 0.70452
ALD4 MSS1 0.69729
ALD4 PGU1 0.69201
ALD4 YER187W 0.68412
ALD4 YAR040C_d 0.6748
ALD4 FLO8 0.67158

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YOR374W

Other databases:

Visit YOR374W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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