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Yeast Fitness
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YOR357C / SNX3



Section 1: Phenotypes.
Gene-drug relationships for YOR357C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOR357C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SNX3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
drofenine hydrochloride 750 uM 7.9536 1.5102e-10
wiskostatin 29 uM 6.30661 2.2405e-07
methotrexate 500 uM 6.29207 2.3362e-07
metergoline 250 uM 5.93317 1.6985e-07
methotrexate 500 uM 5.89455 7.366e-07
itraconazole 17.7 uM 3.89775 0.00015343
itraconazole 17.7 uM 3.82574 0.00019183
berberine chloride 125 uM 3.1626 0.0013694
methotrexate 250 uM 2.94881 0.0024784
miconazole 0.2 uM 2.79408 0.0037546

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SNX3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 22.9917 < 1e-12
cadmium chloride 7.81 uM 15.1519 < 1e-12
hgcl2 62.5 uM 10.7478 < 1e-12
rapamycin 4.88 nM 9.90009 7.5384e-12
clotrimazole 2 uM 7.90247 1.1123e-08
alverine citrate 500 uM 7.82327 1.3411e-08
alverine citrate 500 uM 7.47433 3.0874e-08
nystatin 5 uM 6.24835 6.5075e-07
nystatin 10 uM 5.94986 7.0634e-05
lovastatin 154.5 uM 5.66418 2.9399e-06

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YOR357C

Top 10 functional gene interactors with YOR357C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SNX3 by heterozygous co-sensitivity:

Query Interactor Correlation
SNX3 YHR033W 0.56541
SNX3 VMR1 0.54857
SNX3 YJL016W 0.50935
SNX3 MNN4 0.49845
SNX3 JHD2 0.49334
SNX3 BAP3 0.4904
SNX3 TOK1 0.48768
SNX3 YLR400W 0.47829
SNX3 YPL216W 0.46975
SNX3 YOR289W 0.46616

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SNX3 by homozygous co-sensitivity:

Query Interactor Correlation
SNX3 YML037C 0.64634
SNX3 HSE1 0.63214
SNX3 YGL160W 0.58156
SNX3 ECM37 0.57289
SNX3 YAP1802 0.56674
SNX3 ISW1 0.55574
SNX3 ABP1 0.54465
SNX3 YBR246W 0.53852
SNX3 MVB12 0.53782
SNX3 YOR356W 0.52954

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:




External information about YOR357C

Other databases:

Visit YOR357C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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