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Yeast Fitness
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YOR231W / MKK1



Section 1: Phenotypes.
Gene-drug relationships for YOR231W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOR231W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MKK1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
caspofungin 10 nM 7.92037 1.6912e-10
cantharidin 250 uM 6.49162 0.011459
telomerase inhibitor ix (Biomol) 500 uM 6.27756 2.4358e-07
oxethazine 250 uM 4.47609 2.4107e-05
thiabendazole 500 uM 4.0101 0.00010792
lovastatin 62.5 uM 3.89591 0.00015431
methotrexate 500 uM 3.71311 0.00038917
fenbendazole 500 uM 3.54914 0.0004448
chlorambucil 1000 uM 3.54684 0.00044787
lapachol 1000 uM 3.45882 0.0005817

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MKK1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cadmium chloride 7.81 uM 10.4644 < 1e-12
sorbitol 1.5e+06 uM 10.3581 5.069e-11
minimal media 0 7.26371 5.1459e-08
ph8 0 7.17783 6.3479e-08
latrunculin 0.78 uM 5.85282 0.013987
synthetic complete for BY4743 0 5.18488 0.0017555
acetic acid 50 uM 4.77601 1.6731e-05
nacl 1000 uM 4.48128 0.00058834
allyl disulfide 0.06 % 4.31713 6.4668e-05
mitomycin c 1000 uM 4.24763 7.9185e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YOR231W

Top 10 functional gene interactors with YOR231W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MKK1 by heterozygous co-sensitivity:

Query Interactor Correlation
MKK1 YJU2 0.32285
MKK1 ERV14 0.31625
MKK1 KTI12 0.31121
MKK1 NAT5 0.29794
MKK1 VMA21 0.28131
MKK1 YGL041C 0.28052
MKK1 RAM2 0.27907
MKK1 SEC9 0.27873
MKK1 CNM67 0.27676
MKK1 SAC1 0.27542

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with MKK1 by homozygous co-sensitivity:

Query Interactor Correlation
MKK1 ROM1 0.72058
MKK1 HBT1 0.68338
MKK1 PPN1 0.67549
MKK1 HEH2 0.63506
MKK1 YGL132W 0.59995
MKK1 MCH1 0.59205
MKK1 IFA38 0.57722
MKK1 YPL035C 0.57278
MKK1 LSC2 0.56748
MKK1 GAD1 0.56656

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YOR231W

Other databases:

Visit YOR231W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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