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Yeast Fitness

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YOR224C / RPB8

Section 1: Phenotypes.
Gene-drug relationships for YOR224C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOR224C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPB8 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 6.25 uM 3.04464 0.0038624
cantharidin 250 uM 2.95534 0.04898
bouvardin 1000 uM 2.72704 0.0051422
distamycin a 250 uM 2.6636 0.0060015
cyclamin 62.5 uM 2.6231 0.0066179
neomycin sulfate 100 uM 2.54107 0.0080496
nsc95397 125 uM 2.51999 0.0084609
cinerubin 12.5 uM 2.4921 0.009035
psoralen 62.5 uM 2.47164 0.0094785
cantharidin 250 uM 2.38313 0.070011

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YOR224C

Top 10 functional gene interactors with YOR224C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with RPB8 by heterozygous co-sensitivity:

Query Interactor Correlation
RPB8 SUI2 0.57826
RPB8 RPO26 0.56532
RPB8 RPL17A 0.51675
RPB8 RPL14A 0.50918
RPB8 RPC53 0.50055
RPB8 YDL152W 0.49414
RPB8 RPL19B 0.49225
RPB8 NIP1 0.48898
RPB8 YPL238C 0.48699
RPB8 RPL23B 0.48622

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YOR224C

Other databases:

Visit YOR224C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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