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YOR211C / MGM1



Section 1: Phenotypes.
Gene-drug relationships for YOR211C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOR211C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MGM1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
37 degrees C 0 7.60562 4.9838e-10
methotrexate 500 uM 7.44133 9.0617e-09
cantharidin 250 uM 6.89014 0.010211
dyclonine 500 uM 6.62102 1.5374e-08
thiabendazole 500 uM 6.24852 5.6547e-08
37 degrees C 0 5.67164 4.2114e-07
clozapine 500 uM 4.96962 4.6608e-06
berberine chloride 125 uM 4.57459 1.7436e-05
methotrexate 500 uM 4.34462 6.5905e-05
lovastatin 77.2 uM 4.13565 7.2492e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MGM1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 27.5725 < 1e-12
rapamycin 9 nM 6.18254 0.0042607
rapamycin 9 nM 5.29722 0.016919
carboplatin 700 uM 2.21036 0.020134
licl 100 mM 2.08238 0.025923
synthetic complete for BY4743 0 2.03711 0.028309
latrunculin 0.78 uM 1.81625 0.043012
latrunculin 0.78 uM 1.4477 0.082447
angelicin 62.5 uM 1.31954 0.10176
minimal media 0 1.3143 0.1031

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YOR211C

Top 10 functional gene interactors with YOR211C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MGM1 by heterozygous co-sensitivity:

Query Interactor Correlation
MGM1 RPC31 0.68286
MGM1 DUO1 0.66374
MGM1 NPT1 0.63545
MGM1 SCC2 0.62833
MGM1 MRD1 0.6226
MGM1 DBP7 0.61757
MGM1 NTR2 0.60322
MGM1 MCT1 0.60071
MGM1 RIO2 0.5981
MGM1 PFY1 0.59202

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YOR211C

Other databases:

Visit YOR211C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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