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Yeast Fitness
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YOR188W / MSB1



Section 1: Phenotypes.
Gene-drug relationships for YOR188W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOR188W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MSB1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 74.8444 4.0348e-09
no drug minimal media 0 72.8879 4.6055e-09
no drug minimal media 0 71.8992 4.9306e-09
no drug minimal media 0 68.8723 6.112e-09
no drug minimal media 0 64.5865 8.4243e-09
no drug minimal media 0 59.086 7.8961e-10
no drug minimal media 0 47.2658 3.0056e-09
no drug minimal media 0 33.2024 2.4835e-08
no drug minimal media 0 19.3396 6.1865e-07
dihydromotuporamine C 15 uM 8.21699 1.0945e-09

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MSB1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
23 degrees C 0 8.46967 3.5598e-06
synthetic complete for BY4743 0 6.85306 0.0011866
synthetic complete for BY4743 0 6.02512 0.0045821
ph4 8 5.57824 1.5218e-06
ph4 8 5.5388 1.7126e-06
myriocin 0.2 ug/ml 4.37486 0.00018261
fk506 0.1 ug/ml 4.2536 7.7821e-05
synthetic complete for BY4743 0 3.68119 0.010591
synthetic complete for BY4743 0 3.41355 0.0094852
synthetic complete for BY4743 0 3.18197 0.043095

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YOR188W

Top 10 functional gene interactors with YOR188W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MSB1 by heterozygous co-sensitivity:

Query Interactor Correlation
MSB1 AHA1 0.72973
MSB1 LSC1 0.69863
MSB1 SWH1_p 0.64724
MSB1 YKL121W 0.63069
MSB1 YKL187C 0.60608
MSB1 PSK1 0.60264
MSB1 PDR11 0.59718
MSB1 YDR215C 0.59433
MSB1 SLP1 0.59316
MSB1 MFB1 0.59245

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with MSB1 by homozygous co-sensitivity:

Query Interactor Correlation
MSB1 PRY1 0.65756
MSB1 PMU1 0.65632
MSB1 YJL068C 0.61871
MSB1 ABP140_p 0.61429
MSB1 HSP104 0.61154
MSB1 MDM1 0.60307
MSB1 IME1 0.59896
MSB1 KEL3 0.59499
MSB1 GSP2 0.59492
MSB1 HOS3 0.57851

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YOR188W

Other databases:

Visit YOR188W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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