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Yeast Fitness
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YOR180C / DCI1



Section 1: Phenotypes.
Gene-drug relationships for YOR180C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOR180C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for DCI1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 12.9846 9.996e-09
miconazole 0.2 uM 10.6636 5.5772e-09
ketoconazole 11.8 uM 10.4876 7.0533e-09
dihydromotuporamine C 15 uM 10.1389 8.0805e-12
nacl 700 mM 9.72822 2.2148e-11
papuamide b 0.125 ug/ml 7.99345 1.9979e-09
nocodazole 2 ug/ml 5.90921 1.8462e-07
methotrexate 125 uM 5.72806 1.1943e-06
splitomicin 250 uM 5.70805 1.2658e-06
tryptanthrin 250 uM 5.11305 7.1519e-06

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for DCI1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
23 degrees C 0 8.48167 3.5154e-06
cadmium chloride 7.81 uM 3.17279 0.0015983
lysine dropout 0 2.4658 0.012304
carboplatin 700 uM 2.18194 0.021306
wiskostatin 29 uM 2.07134 0.022992
nystatin 10 uM 2.05059 0.033721
thimerosal 125 nM 2.01955 0.029287
ph4 7.5 1.89044 0.037455
threonine dropout 0 1.78275 0.046246
sorbitol 1.5e+06 uM 1.76363 0.054132

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YOR180C

Top 10 functional gene interactors with YOR180C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with DCI1 by heterozygous co-sensitivity:

Query Interactor Correlation
DCI1 OST5 0.7375
DCI1 GSP2 0.72997
DCI1 NGL3 0.72321
DCI1 YOR175C 0.69378
DCI1 YDR157W 0.68233
DCI1 STE13 0.67724
DCI1 LYS4 0.67136
DCI1 RAD9 0.66839
DCI1 HST4 0.66092
DCI1 YDL094C 0.63996

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with DCI1 by homozygous co-sensitivity:

Query Interactor Correlation
DCI1 ITT1 0.78716
DCI1 GAS2 0.76424
DCI1 YJR100C 0.76168
DCI1 ECM27 0.73504
DCI1 YJR098C 0.72891
DCI1 YCL074W 0.71671
DCI1 XPT1 0.71482
DCI1 YOR131C 0.70619
DCI1 YHB1 0.69802
DCI1 YCL023C 0.6974

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YOR180C

Other databases:

Visit YOR180C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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