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YOR163W / DDP1



Section 1: Phenotypes.
Gene-drug relationships for YOR163W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOR163W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for DDP1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 2 ug/ml 21.1104 < 1e-12
miconazole 0.2 uM 20.0285 < 1e-12
lapachol 500 uM 17.065 < 1e-12
ketoconazole 11.8 uM 15.7373 1.8565e-11
papuamide b 0.125 ug/ml 11.7861 < 1e-12
alverine citrate 500 uM 5.93017 3.4611e-05
cantharidin 250 uM 5.867 0.013922
5-fluorocytosine 15.6 uM 5.85351 2.2408e-07
5-fluorouracil 76.9 uM 4.44023 2.7109e-05
itraconazole 17.7 uM 3.74605 0.00024513

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for DDP1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mms 0.002 % 12.9305 0.0029639
acetic acid 50 uM 8.44373 3.6742e-10
23 degrees C 0 7.50302 1.0278e-05
synthetic complete for BY4743 0 7.41816 7.3568e-05
cisplatin 125 uM 7.24102 5.4388e-08
cadmium chloride 7.81 uM 6.17871 2.5264e-07
synthetic complete for BY4743 0 5.47964 0.015864
sorbitol 1.5e+06 uM 4.97974 1.7725e-05
mechlorethamine 62.5 uM 4.67564 0.021413
nacl 700 uM 4.62087 2.6492e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YOR163W

Top 10 functional gene interactors with YOR163W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with DDP1 by heterozygous co-sensitivity:

Query Interactor Correlation
DDP1 TMA16 0.53225
DDP1 IES4 0.52035
DDP1 MET7 0.51699
DDP1 IRC13 0.49305
DDP1 VPS64 0.49142
DDP1 ERJ5 0.46093
DDP1 YKL169C 0.45749
DDP1 VMA21 0.4574
DDP1 MRPL31 0.45593
DDP1 ODC2 0.45445

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with DDP1 by homozygous co-sensitivity:

Query Interactor Correlation
DDP1 ECM4 0.6084
DDP1 YRM1 0.59625
DDP1 TOS8 0.55573
DDP1 AVT6 0.54352
DDP1 YFL051C 0.54249
DDP1 YLR326W 0.53585
DDP1 NGL1 0.53172
DDP1 DOT5 0.52897
DDP1 FAU1 0.52239
DDP1 YER152C 0.51504

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YOR163W

Other databases:

Visit YOR163W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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