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YOR117W / RPT5

Section 1: Phenotypes.
Gene-drug relationships for YOR117W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOR117W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPT5 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 12.3929 < 1e-12
methotrexate 500 uM 11.6365 < 1e-12
methotrexate 500 uM 10.4998 3.3913e-12
lapachol 1000 uM 9.12229 4.4726e-12
mitomycin c 1000 uM 8.79421 1.0166e-11
telomerase inhibitor ix (Biomol) 500 uM 8.71058 2.9637e-10
amphotericin b 10 uM 8.05305 1.0777e-10
methotrexate 250 uM 7.5615 6.501e-09
methotrexate 500 uM 6.70399 7.1889e-08
methotrexate 250 uM 6.53337 1.1694e-07

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YOR117W

Top 10 functional gene interactors with YOR117W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with RPT5 by heterozygous co-sensitivity:

Query Interactor Correlation
RPT5 RPT6 0.75234
RPT5 RPT4 0.74979
RPT5 GPI19 0.74153
RPT5 RPN12 0.70479
RPT5 RPN8 0.6922
RPT5 RPN3 0.68815
RPT5 RPN6 0.64987
RPT5 RPT2 0.63274
RPT5 RPT1 0.60991
RPT5 RPT3 0.60457

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YOR117W

Other databases:

Visit YOR117W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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