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Yeast Fitness
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YOR098C / NUP1



Section 1: Phenotypes.
Gene-drug relationships for YOR098C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOR098C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for NUP1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 250 uM 12.7274 < 1e-12
5-fluorouracil 38.4 uM 9.87291 1.5486e-11
methotrexate 250 uM 9.10507 1.067e-10
wiskostatin 29 uM 9.02132 1.3232e-10
tryptanthrin 250 uM 8.55877 4.4148e-10
methotrexate 500 uM 8.48672 5.3394e-10
methotrexate 500 uM 8.25286 9.9436e-10
dna protein kinase inhibitor 0 8.01887 1.8651e-09
methotrexate 500 uM 7.37486 1.0896e-08
dyclonine 500 uM 7.10948 6.157e-06

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YOR098C

Top 10 functional gene interactors with YOR098C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with NUP1 by heterozygous co-sensitivity:

Query Interactor Correlation
NUP1 ORC1 0.65579
NUP1 LCD1 0.65364
NUP1 RFA2 0.63882
NUP1 SSY1 0.62711
NUP1 YML012C-A 0.61986
NUP1 SPT10 0.6111
NUP1 YML6 0.60293
NUP1 YML009W-B 0.60228
NUP1 RAI1 0.60114
NUP1 SEC59 0.59979

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YOR098C

Other databases:

Visit YOR098C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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