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Yeast Fitness
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YOL147C / PEX11



Section 1: Phenotypes.
Gene-drug relationships for YOL147C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOL147C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PEX11 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 8.87042 7.0828e-08
miconazole 100 uM 4.24269 5.1451e-05
propiomazine maleate 500 uM 4.23231 5.3198e-05
thiabendazole 500 uM 3.96933 0.00012267
5-fluorocytosine 15.6 uM 3.90497 0.00015002
itraconazole 8.8 uM 3.50186 0.00051209
clotrimazole 1 uM 3.44989 0.00059725
tunicamycin 0.15 uM 3.25475 0.0024855
miconazole 100 uM 3.20958 0.0011986
floxuridine 80000 uM 3.13459 0.0014819

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PEX11 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 6.28967 5.8559e-07
mitomycin c 1000 uM 6.25408 3.3631e-06
cisplatin 500 uM 4.83116 2.6238e-05
methotrexate 250 uM 4.45213 7.1363e-05
latrunculin 3 uM 3.9474 0.00047211
cisplatin 62.5 uM 3.8118 0.00038114
cisplatin 66 uM 3.72958 0.00047129
cisplatin 125 uM 3.67725 0.0005392
aklavin hydrochloride 250 uM 3.53306 0.00077972
acriflavinium hydrochloride 250 uM 3.46075 0.00093691

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YOL147C

Top 10 functional gene interactors with YOL147C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with PEX11 by heterozygous co-sensitivity:

Query Interactor Correlation
PEX11 ARN2 0.57213
PEX11 MNT3 0.52264
PEX11 MBF1 0.51181
PEX11 TRM10 0.51059
PEX11 RPL41B_p 0.5025
PEX11 YKR106W 0.49375
PEX11 VMR1 0.48394
PEX11 YHR033W 0.48349
PEX11 MDY2 0.48055
PEX11 POM152 0.47935

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with PEX11 by homozygous co-sensitivity:

Query Interactor Correlation
PEX11 UGA4 0.75878
PEX11 PAU8 0.753
PEX11 DCS2 0.74855
PEX11 YCR100C 0.74226
PEX11 IRC7 0.74085
PEX11 NFT1 0.73865
PEX11 YLR104W 0.72895
PEX11 FRM2 0.728
PEX11 SSF2 0.72064
PEX11 YOR114W 0.71768

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YOL147C

Other databases:

Visit YOL147C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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