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Yeast Fitness
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YOL122C / SMF1



Section 1: Phenotypes.
Gene-drug relationships for YOL122C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOL122C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SMF1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 6.62531 0.00028493
miconazole 100 uM 3.97516 0.00012045
fluconazole 65.3 uM 3.63363 0.00034506
lapachol 500 uM 3.52775 0.00047413
itraconazole 17.7 uM 3.44989 0.00059725
itraconazole 17.7 uM 3.22342 0.0011523
rhizoxin 200 uM 2.80171 0.0036795
fluconazole 130.6 uM 2.70251 0.0047727
splitomicin 250 uM 2.66932 0.0059189
haloperidol 250 uM 2.54031 0.012962

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SMF1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
licl 100 mM 9.38945 1.1668e-08
papuamide b 1 ug/ml 5.77857 8.3507e-07
licl 150 mM 4.32389 6.3404e-05
fk506 200 uM 3.64261 0.00044499
licl 150 mM 3.60226 0.00049786
ph8 0 3.45557 0.0030842
fk506 100 uM 3.41419 0.00083534
mechlorethamine 62.5 uM 3.32043 0.02252
papuamide b 0.37 ug/ml 3.29212 0.0020256
carboplatin 15 mM 3.12723 0.0029109

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YOL122C

Top 10 functional gene interactors with YOL122C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SMF1 by heterozygous co-sensitivity:

Query Interactor Correlation
SMF1 HFA1 0.56308
SMF1 MSC6 0.5528
SMF1 SEO1 0.53959
SMF1 YJL152W 0.53731
SMF1 JJJ2 0.53258
SMF1 DIN7 0.52613
SMF1 YGR018C 0.51412
SMF1 YLR030W 0.51084
SMF1 YGR022C 0.50836
SMF1 FKH2 0.50709

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with SMF1 by homozygous co-sensitivity:

Query Interactor Correlation
SMF1 YPL056C 0.70398
SMF1 YJL070C 0.6736
SMF1 YGR139W 0.64293
SMF1 MSH6 0.62505
SMF1 YMR144W 0.58651
SMF1 YPL033C 0.58589
SMF1 NFI1 0.558
SMF1 YNR025C 0.55481
SMF1 YIR044C 0.54998
SMF1 YOR238W 0.54908

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YOL122C

Other databases:

Visit YOL122C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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