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Yeast Fitness

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YOL102C / TPT1

Section 1: Phenotypes.
Gene-drug relationships for YOL102C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOL102C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TPT1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 9.35885 3.4251e-08
miconazole 100 uM 6.35523 3.8944e-08
trichostatin A 3.91 uM 6.0981 4.0868e-07
tunicamycin 0.15 uM 5.71417 1.5983e-05
mitomycin c 1000 uM 5.52704 6.9419e-07
miconazole 50 nM 3.80134 0.00020684
clotrimazole 1 uM 3.75898 0.0002356
cantharidin 250 uM 3.66541 0.033517
5-fluorocytosine 15.6 uM 3.64883 0.00032957
phenoxybenzamine hydrochloride 500 uM 3.26441 0.0010247

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YOL102C

Top 10 functional gene interactors with YOL102C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with TPT1 by heterozygous co-sensitivity:

Query Interactor Correlation
TPT1 FAD1 0.67778
TPT1 NSE5 0.59234
TPT1 CAX4 0.5878
TPT1 RMD9 0.58411
TPT1 BUD14 0.57744
TPT1 OST1 0.56376
TPT1 YDL032W 0.55908
TPT1 MRPL49 0.55691
TPT1 TAF4 0.55069
TPT1 RIC1 0.55013

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YOL102C

Other databases:

Visit YOL102C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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