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YOL081W / IRA2



Section 1: Phenotypes.
Gene-drug relationships for YOL081W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOL081W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for IRA2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 16.5705 8.5069e-12
clozapine 500 uM 13.4733 < 1e-12
aphidicolin glycinate 125 uM 10.284 5.6876e-12
bithionol 75 uM 8.10444 9.0616e-11
bithionol 75 uM 7.93245 1.623e-10
alverine citrate 500 uM 7.66895 0.0082907
bithionol 75 uM 7.54715 6.0998e-10
itraconazole 4.4 uM 6.79189 8.4583e-09
acriflavinium hydrochloride 250 uM 6.66679 1.31e-08
alverine citrate 500 uM 6.61433 0.011051

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for IRA2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 7.93475 0.0020871
synthetic complete for BY4743 0 7.44298 0.00034515
synthetic complete for BY4743 0 7.10734 0.00042734
synthetic complete for BY4743 0 6.4022 3.9052e-05
synthetic complete for BY4743 0 6.10802 5.7238e-05
synthetic complete for BY4743 0 5.81724 0.0010596
synthetic complete for BY4743 0 5.80879 0.0010665
yp glycerol 0 5.35896 0.00015975
yp glycerol 0 4.93866 0.00029417
nacl 1000 uM 4.86659 0.00032747

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YOL081W

Top 10 functional gene interactors with YOL081W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with IRA2 by heterozygous co-sensitivity:

Query Interactor Correlation
IRA2 GDT1 0.55942
IRA2 BCY1 0.55284
IRA2 PSY2 0.505
IRA2 RXT2 0.49105
IRA2 BEM2 0.44119
IRA2 MTM1 0.44007
IRA2 HRR25 0.43359
IRA2 RPA14 0.4296
IRA2 CKA1 0.41096
IRA2 MMS22 0.40871

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with IRA2 by homozygous co-sensitivity:

Query Interactor Correlation
IRA2 PDE2 0.70373
IRA2 YME1 0.49122
IRA2 FYV10 0.49105
IRA2 RTT107 0.43324
IRA2 IRC4 0.41606
IRA2 FBP26 0.41484
IRA2 ARP6 0.3945
IRA2 TOM7 0.3823
IRA2 DBF2 0.37944
IRA2 VPS71 0.37605

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YOL081W

Other databases:

Visit YOL081W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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