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YOL039W / RPP2A



Section 1: Phenotypes.
Gene-drug relationships for YOL039W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOL039W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPP2A Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
berberine chloride 125 uM 6.41389 3.1724e-08
licl 150 mM 6.21133 2.9477e-07
fendiline hydrochloride 125 uM 6.17295 7.3624e-08
thiabendazole 500 uM 5.94339 1.6392e-07
itraconazole 17.7 uM 5.69587 3.8725e-07
itraconazole 17.7 uM 5.6448 4.6215e-07
fluconazole 130.6 uM 5.54405 6.5462e-07
telomerase inhibitor ix (Biomol) 500 uM 4.58084 3.3449e-05
dyclonine 500 uM 4.46323 2.5144e-05
drofenine hydrochloride 750 uM 4.45963 2.5442e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPP2A Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
licl 100 mM 7.88183 1.5136e-07
potassium disulfite 2500 uM 6.01328 5.4839e-06
hygromycin 13.75 uM 4.84726 1.3538e-05
norcantharidin 2500 uM 4.64006 2.5031e-05
cycloheximide 32.3 uM 3.58042 0.00052895
adenine dropout 0 2.90526 0.0049261
streptovitacin 31.25 uM 2.86946 0.0035105
synthetic complete for BY4743 0 2.75978 0.010069
cuso4 12000 uM 2.42055 0.011392
licl 150 mM 2.27954 0.014515

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YOL039W

Top 10 functional gene interactors with YOL039W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPP2A by heterozygous co-sensitivity:

Query Interactor Correlation
RPP2A PRO2 0.43784
RPP2A UBC11 0.43094
RPP2A SYS1 0.42176
RPP2A STB1 0.41532
RPP2A CTM1 0.41324
RPP2A SPO7 0.4104
RPP2A SEL1 0.40632
RPP2A PET123 0.40548
RPP2A RIB2 0.40506
RPP2A YML6 0.3943

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RPP2A by homozygous co-sensitivity:

Query Interactor Correlation
RPP2A RPL36A 0.71225
RPP2A RPL33B 0.70376
RPP2A YML108W 0.68178
RPP2A RPL26A 0.66689
RPP2A RPL2A 0.66612
RPP2A RPL8B 0.66441
RPP2A YDL062W 0.65899
RPP2A YMR193C-A 0.65814
RPP2A YDL063C 0.63682
RPP2A RPL27B 0.63404

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YOL039W

Other databases:

Visit YOL039W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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