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Yeast Fitness

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YOL038W / PRE6

Section 1: Phenotypes.
Gene-drug relationships for YOL038W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOL038W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PRE6 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fenpropimorph 4.7 uM 17.9249 < 1e-12
alverine citrate 500 uM 12.0916 0.0033851
fenpropimorph 1.65 nM 11.4759 4.4019e-05
alverine citrate 500 uM 10.9293 0.004134
dyclonine 500 uM 10.0253 < 1e-12
clozapine 500 uM 9.43809 2.6253e-12
licl 150 mM 9.271 6.9852e-11
dyclonine 500 uM 8.85093 6.583e-07
alverine citrate 500 uM 8.50229 2.4529e-11
dyclonine 500 uM 8.20929 6.3772e-11

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YOL038W

Top 10 functional gene interactors with YOL038W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with PRE6 by heterozygous co-sensitivity:

Query Interactor Correlation
PRE6 PRE3 0.80767
PRE6 PUP1 0.76291
PRE6 PUP3 0.75901
PRE6 SCL1 0.72237
PRE6 PRE2 0.68928
PRE6 PUP2 0.68351
PRE6 PRE1 0.67553
PRE6 PRE7 0.64876
PRE6 UMP1 0.64718
PRE6 PRE5 0.60974

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YOL038W

Other databases:

Visit YOL038W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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