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Yeast Fitness

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YOL021C / DIS3

Section 1: Phenotypes.
Gene-drug relationships for YOL021C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOL021C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for DIS3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorocytosine 15.6 uM 6.09254 9.7475e-08
amphotericin b 0.62 uM 5.93162 1.7077e-07
amphotericin b 0.62 uM 5.418 1.0105e-06
amphotericin b 0.31 uM 5.27674 1.6405e-06
5-fluorocytosine 15.6 uM 5.09175 3.0822e-06
5-fluorouracil 125 uM 4.95564 4.886e-06
5-fluorouridine 23.8 uM 4.87412 6.4292e-06
5-fluorocytosine 15.6 uM 4.75489 9.5844e-06
fenpropimorph 8 nM 4.70812 1.1201e-05
amphotericin b 0.31 uM 4.70205 1.143e-05

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YOL021C

Top 10 functional gene interactors with YOL021C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with DIS3 by heterozygous co-sensitivity:

Query Interactor Correlation
DIS3 RRP42 0.56956
DIS3 RRP46 0.54157
DIS3 NOP2 0.52571
DIS3 RRP45 0.50379
DIS3 MTR3 0.49158
DIS3 YPR142C 0.48539
DIS3 PAP2 0.4635
DIS3 YDL144C 0.46121
DIS3 NOP4 0.45556
DIS3 RLP7 0.43677

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YOL021C

Other databases:

Visit YOL021C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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