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Yeast Fitness

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YOL010W / RCL1

Section 1: Phenotypes.
Gene-drug relationships for YOL010W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOL010W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RCL1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
drofenine hydrochloride 750 uM 5.47463 8.3163e-07
5-fluorouracil 38.5 uM 4.24759 0.00030714
clozapine 500 uM 4.22539 5.4395e-05
methotrexate 250 uM 3.06088 0.0022221
osajin 1000 uM 2.84929 0.003242
allyl sulfide 0.12 % 2.83228 0.0039651
fecl4 2500 uM 2.80616 0.0042311
dihydromotuporamine C 15 uM 2.79634 0.0043353
norcantharidin 2500 uM 2.67376 0.0058554
papuamide b 0.125 ug/ml 2.54861 0.0079069

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YOL010W

Top 10 functional gene interactors with YOL010W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with RCL1 by heterozygous co-sensitivity:

Query Interactor Correlation
RCL1 SME1 0.62851
RCL1 YOR292C 0.6175
RCL1 BUD22 0.60999
RCL1 FUM1 0.59601
RCL1 NAT3 0.58887
RCL1 ERP2 0.57662
RCL1 AFR1 0.56772
RCL1 HEM4 0.56766
RCL1 YDL094C 0.56537
RCL1 YDR157W 0.56105

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YOL010W

Other databases:

Visit YOL010W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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