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YOL005C / RPB11

Section 1: Phenotypes.
Gene-drug relationships for YOL005C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOL005C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPB11 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
caspofungin 10 nM 12.3268 < 1e-12
latrunculin 3.91 uM 11.6924 < 1e-12
caspofungin 10 nM 9.24121 3.5429e-12
caspofungin 10 nM 9.16111 4.1275e-12
wiskostatin 29 uM 8.63119 3.6491e-10
clozapine 500 uM 7.65264 4.2374e-10
caspofungin 10 nM 6.7483 9.8509e-09
itraconazole 4.4 uM 5.29937 1.5183e-06
itraconazole 8.8 uM 5.12852 2.7201e-06
alverine citrate 500 uM 5.1001 0.018181

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YOL005C

Top 10 functional gene interactors with YOL005C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with RPB11 by heterozygous co-sensitivity:

Query Interactor Correlation
RPB11 YDL211C 0.60534
RPB11 RPB2 0.56845
RPB11 SPC29 0.51706
RPB11 FCP1 0.51449
RPB11 RPB4 0.50331
RPB11 ZDS1 0.47338
RPB11 RPB7 0.46967
RPB11 YJR023C 0.46875
RPB11 SEC4 0.46801
RPB11 RPB9 0.43962

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YOL005C

Other databases:

Visit YOL005C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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