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Yeast Fitness
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YOL004W / SIN3



Section 1: Phenotypes.
Gene-drug relationships for YOL004W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YOL004W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SIN3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
licl 150 mM 10.6659 2.2872e-12
fk506 0.1 ug/ml 9.06584 1.18e-10
fk506 0.1 ug/ml 8.6407 3.5591e-10
nacl 700 mM 5.24586 4.8589e-06
fluconazole 130.6 uM 5.15333 2.4999e-06
nacl 700 mM 4.84298 1.5674e-05
nacl 700 mM 4.67292 2.5644e-05
itraconazole 17.7 uM 4.51579 2.1162e-05
itraconazole 17.7 uM 4.45995 2.5416e-05
licl 150 mM 4.43628 5.069e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SIN3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 15.6083 0.00028576
nystatin 10 uM 5.84922 9.6647e-06
latrunculin 0.78 uM 4.08195 0.00034988
nystatin 10 uM 4.00211 0.00046149
latrunculin 0.78 uM 3.7003 0.00081878
sorbitol 1.5e+06 uM 2.82162 0.0090551
psoralen 0.5 uM 2.74388 0.0066727
acetic acid 50 uM 2.738 0.0048823
cantharidin analog 250 ug/ml 2.62766 0.0064033
cisplatin 133.2 uM 2.2818 0.015465

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YOL004W

Top 10 functional gene interactors with YOL004W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SIN3 by heterozygous co-sensitivity:

Query Interactor Correlation
SIN3 BRL1 0.52707
SIN3 RPL3 0.5231
SIN3 PSF2 0.50579
SIN3 PIH1 0.50521
SIN3 VRP1 0.4988
SIN3 SED5 0.49874
SIN3 SMT3 0.49402
SIN3 GAL83 0.49155
SIN3 YCR064C 0.49081
SIN3 YDR442W 0.48864

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with SIN3 by homozygous co-sensitivity:

Query Interactor Correlation
SIN3 DEP1 0.49419
SIN3 PDA1 0.43284
SIN3 TOS1 0.40742
SIN3 MCT1 0.40602
SIN3 DPH1 0.40231
SIN3 YKL131W 0.40136
SIN3 YCL076W 0.39831
SIN3 FMP43 0.39732
SIN3 YOR152C 0.39161
SIN3 YGL072C 0.39149

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YOL004W

Other databases:

Visit YOL004W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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