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YNL338W / YNL338W



Section 1: Phenotypes.
Gene-drug relationships for YNL338W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YNL338W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YNL338W Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
lapachol 500 uM 6.16772 7.498e-08
methotrexate 500 uM 5.1715 6.0333e-06
itraconazole 17.7 uM 4.75628 9.5398e-06
doxorubicin 62.5 uM 4.5751 1.7407e-05
itraconazole 17.7 uM 4.57199 1.7587e-05
miconazole 100 uM 4.33314 3.8416e-05
5-fluorocytosine 15.6 uM 3.58297 0.00040194
norcantharidin 2500 uM 3.39713 0.00091844
trichostatin A 3.91 uM 3.35928 0.0010162
methotrexate 250 uM 3.12648 0.0018755

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YNL338W Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 5.46216 2.1548e-06
cadmium chloride 7.81 uM 5.39901 2.6037e-06
l-dopa 12.5 ug/ml 4.42246 4.7516e-05
licl 100 mM 3.95512 0.00046407
synthetic complete for BY4743 0 3.13716 0.025889
methoxsalen 500 uM 2.84372 0.0042856
nocodazole 10 ug/ml 2.52018 0.010695
synthetic complete for BY4743 0 2.4286 0.017768
5-fluorouracil 38.46 uM 2.02235 0.035351
synthetic complete for BY4743 400 uM 1.89245 0.043853

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YNL338W

Top 10 functional gene interactors with YNL338W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YNL338W by heterozygous co-sensitivity:

Query Interactor Correlation
YNL338W YHR113W 0.48173
YNL338W YOL053W 0.47099
YNL338W CSI2 0.46999
YNL338W YLL056C 0.46626
YNL338W GRE2 0.46409
YNL338W MEK1 0.45135
YNL338W ATG13 0.43887
YNL338W TOS2 0.41881
YNL338W YNL211C 0.4161
YNL338W SSE2 0.41409

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YNL338W by homozygous co-sensitivity:

Query Interactor Correlation
YNL338W HSP104 0.70071
YNL338W YHR127W 0.69735
YNL338W YBR239C 0.67051
YNL338W CPD1 0.65831
YNL338W YLR408C 0.65748
YNL338W MDM1 0.65495
YNL338W YMR306C-A 0.65272
YNL338W PRY1 0.6521
YNL338W IME1 0.65121
YNL338W YOL053W 0.62641

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YNL338W

Other databases:

Visit YNL338W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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