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Yeast Fitness
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YNL293W / MSB3



Section 1: Phenotypes.
Gene-drug relationships for YNL293W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YNL293W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MSB3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 6.80679 2.1073e-06
dyclonine 500 uM 6.13297 2.5378e-05
propiomazine maleate 500 uM 5.6738 4.18e-07
itraconazole 4.4 uM 5.21874 2.0002e-06
tryptanthrin 250 uM 5.04526 8.7109e-06
dyclonine 500 uM 5.02982 0.00014713
dihydromotuporamine C 15 uM 4.62875 2.9132e-05
clotrimazole 1 uM 4.46447 2.5042e-05
no drug minimal media 0 4.39634 0.0022932
bufexamac 1000 uM 4.04059 9.8019e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MSB3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nacl 600 mM 26.8006 < 1e-12
cadmium chloride 7.81 uM 19.5119 < 1e-12
cuso4 12000 uM 15.0826 < 1e-12
fk506 0.05 ug/ml 14.3771 < 1e-12
nacl 1000 uM 11.9092 1.5688e-07
nacl 1000 uM 11.7729 1.7478e-07
wiskostatin 29 uM 10.4326 < 1e-12
miconazole 100 uM 10.3127 5.5619e-11
fk506 0.1 ug/ml 8.46821 3.4341e-10
allyl disulfide 0.06 % 8.26964 5.9536e-10

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YNL293W

Top 10 functional gene interactors with YNL293W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MSB3 by heterozygous co-sensitivity:

Query Interactor Correlation
MSB3 ARN2 0.45033
MSB3 PEX22 0.44434
MSB3 TRE1 0.43011
MSB3 YSR3 0.42684
MSB3 YOR053W 0.42651
MSB3 THI7 0.41989
MSB3 UBP12 0.41775
MSB3 PHO90 0.41603
MSB3 YOR041C 0.41324
MSB3 SEO1 0.41121

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with MSB3 by homozygous co-sensitivity:

Query Interactor Correlation
MSB3 YOL048C 0.66384
MSB3 YLR408C 0.65694
MSB3 PAA1 0.64971
MSB3 CUP9 0.63673
MSB3 DAL5 0.60938
MSB3 YOX1 0.57609
MSB3 DNM1 0.57117
MSB3 AQY2 0.56766
MSB3 YNL086W 0.56652
MSB3 YVC1 0.56445

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:




External information about YNL293W

Other databases:

Visit YNL293W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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