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Yeast Fitness
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YNL242W / ATG2



Section 1: Phenotypes.
Gene-drug relationships for YNL242W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YNL242W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ATG2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 6.81469 2.0779e-06
nacl 700 mM 4.25065 8.6167e-05
thiabendazole 500 uM 3.68512 0.00029521
cantharidin 250 uM 3.61436 0.034374
methotrexate 500 uM 2.88489 0.0034763
methotrexate 500 uM 2.84378 0.0038531
berberine chloride 125 uM 2.62362 0.0058476
daunorubicin 125 uM 2.49947 0.007994
licl 150 mM 2.4758 0.0093867
5-fluorouracil 76.8 uM 2.40692 0.011016

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ATG2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 3.47557 0.0051639
synthetic complete for BY4743 0 3.32069 0.0063765
ph4 8 3.01892 0.0023925
synthetic complete for BY4743 0 3.01689 0.0097358
ph4 8 2.96392 0.0027578
k2cr2o7 125 uM 2.76036 0.0046183
5-fluorouracil 19.2 uM 2.56798 0.013994
mms 0.002 % 1.91873 0.035509
25 degrees C 0 1.79963 0.051057
camptothecin 30 ug/ml 1.62934 0.060308

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YNL242W

Top 10 functional gene interactors with YNL242W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ATG2 by heterozygous co-sensitivity:

Query Interactor Correlation
ATG2 YGR001C 0.74902
ATG2 YKL131W 0.72979
ATG2 YKR012C 0.7001
ATG2 YKL100C 0.69936
ATG2 SHE2 0.69374
ATG2 YGL260W 0.68973
ATG2 FAU1 0.68484
ATG2 CUL3 0.68298
ATG2 YKL105C 0.67924
ATG2 YKL187C 0.67877

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ATG2 by homozygous co-sensitivity:

Query Interactor Correlation
ATG2 YIL059C 0.85033
ATG2 HIS3 0.83419
ATG2 HOS3 0.82897
ATG2 TOS2 0.82852
ATG2 YOR289W 0.82723
ATG2 YNL092W 0.82191
ATG2 YOR111W 0.80919
ATG2 YER187W 0.80009
ATG2 ISU2 0.79627
ATG2 YGL260W 0.78368

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YNL242W

Other databases:

Visit YNL242W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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