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YNL231C / PDR16



Section 1: Phenotypes.
Gene-drug relationships for YNL231C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YNL231C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PDR16 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fluconazole 32.6 uM 23.103 < 1e-12
clotrimazole 1 uM 22.0009 < 1e-12
dyclonine 500 uM 21.5208 < 1e-12
itraconazole 8.8 uM 19.1248 < 1e-12
itraconazole 8.8 uM 18.6982 < 1e-12
itraconazole 4.4 uM 18.6162 < 1e-12
itraconazole 8.8 uM 18.5482 < 1e-12
itraconazole 4.4 uM 18.3989 < 1e-12
itraconazole 8.8 uM 18.2279 < 1e-12
itraconazole 37.6 uM 17.9902 < 1e-12

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PDR16 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 50 nM 20.7348 < 1e-12
miconazole 50 nM 20.4059 < 1e-12
chemdiv 275 62 uM 18.5552 < 1e-12
synthetic complete for BY4743 0 18.0843 2.8648e-09
synthetic complete for BY4743 0 18.0331 2.9448e-09
clotrimazole 2 uM 16.6777 < 1e-12
clotrimazole 1 uM 14.7691 < 1e-12
miconazole 50 nM 14.1642 < 1e-12
cocl2 1250 uM 13.5681 < 1e-12
synthetic complete for BY4743 0 11.6257 1.9667e-07

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YNL231C

Top 10 functional gene interactors with YNL231C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with PDR16 by heterozygous co-sensitivity:

Query Interactor Correlation
PDR16 ERG11 0.57874
PDR16 YGL199C 0.56494
PDR16 YOR345C 0.47639
PDR16 PDR1 0.47598
PDR16 YOR379C 0.44296
PDR16 PGD1 0.43373
PDR16 YGL235W 0.42832
PDR16 YDR271C 0.41644
PDR16 YGR022C 0.41538
PDR16 ISU1 0.41505

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with PDR16 by homozygous co-sensitivity:

Query Interactor Correlation
PDR16 YHR045W 0.53099
PDR16 GCN3 0.47561
PDR16 TRP3 0.46547
PDR16 DAP1 0.45891
PDR16 EMP46 0.45854
PDR16 YPR089W_p 0.44138
PDR16 ELA1 0.43101
PDR16 TVP18 0.42885
PDR16 YOR379C 0.42095
PDR16 YLL014W 0.40904

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YNL231C

Other databases:

Visit YNL231C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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