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YNL172W / APC1

Section 1: Phenotypes.
Gene-drug relationships for YNL172W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YNL172W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for APC1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dihydromotuporamine C 15 uM 6.36873 1.8743e-07
nacl 700 mM 5.4207 2.9204e-06
tryptanthrin 250 uM 2.90023 0.0033448
dihydromotuporamine C 7.5 uM 2.44286 0.010136
5-fluorouracil 125 uM 2.23045 0.015265
5-fluorouracil 19.2 uM 2.19115 0.021794
dmso 4% 4 uM 2.16831 0.017615
nocodazole 6.9 uM 2.13223 0.04308
fk506 0.1 ug/ml 2.12339 0.020774
fk506 0.1 ug/ml 2.07565 0.023022

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YNL172W

Top 10 functional gene interactors with YNL172W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with APC1 by heterozygous co-sensitivity:

Query Interactor Correlation
APC1 YNL171C 0.66111
APC1 CDC1 0.65281
APC1 GPM1 0.62034
APC1 CEG1 0.61015
APC1 ILS1 0.60671
APC1 GLE2 0.60348
APC1 FUS3 0.59909
APC1 YNL170W 0.58559
APC1 FBP1 0.5748
APC1 PFY1 0.56802

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YNL172W

Other databases:

Visit YNL172W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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