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Yeast Fitness
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YNL148C / ALF1



Section 1: Phenotypes.
Gene-drug relationships for YNL148C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YNL148C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ALF1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
thiabendazole 250 uM 5.82565 2.4685e-07
thiabendazole 500 uM 5.56497 6.09e-07
no drug minimal media 0 5.05639 0.001956
thiabendazole 500 uM 4.95454 4.9042e-06
5-fluorouracil 19.2 uM 4.94351 1.1708e-05
no drug minimal media 0 4.5043 0.0031871
dna protein kinase inhibitor 0 4.46146 4.7155e-05
methotrexate 500 uM 4.41682 5.3599e-05
AG 957 (Biomol) 500 uM 4.25186 8.5872e-05
no drug minimal media 0 4.19496 0.0042654

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ALF1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 9.15552 1.9077e-05
synthetic complete for BY4743 0 8.09736 0.00063217
synthetic complete for BY4743 0 7.35317 7.7755e-05
synthetic complete for BY4743 0 7.3314 0.00092117
synthetic complete for BY4743 0 6.97793 0.00046508
synthetic complete for BY4743 0 6.45691 0.00066306
benomyl 10 ug/ml 5.79857 8.5346e-06
synthetic complete for BY4743 0 5.79591 0.00033316
synthetic complete for BY4743 0 4.95182 0.0021391
synthetic complete for BY4743 0 4.53248 0.0013459

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YNL148C

Top 10 functional gene interactors with YNL148C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ALF1 by heterozygous co-sensitivity:

Query Interactor Correlation
ALF1 RIO2 0.78301
ALF1 BRR2 0.74338
ALF1 SLA2 0.73983
ALF1 IPI3 0.72536
ALF1 MGE1 0.71721
ALF1 YDR196C 0.71149
ALF1 YGL074C 0.71081
ALF1 SSY1 0.71075
ALF1 PRP40 0.70115
ALF1 GRX5 0.70105

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with ALF1 by homozygous co-sensitivity:

Query Interactor Correlation
ALF1 LEA1 0.50329
ALF1 GCN5 0.44356
ALF1 SLX8 0.44104
ALF1 PHO88 0.43673
ALF1 BRR1 0.43483
ALF1 IST3 0.42314
ALF1 YOR051C 0.4182
ALF1 VRP1 0.41154
ALF1 MSL1 0.41134
ALF1 GIT1 0.40986

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None




External information about YNL148C

Other databases:

Visit YNL148C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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