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YNL041C / COG6



Section 1: Phenotypes.
Gene-drug relationships for YNL041C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YNL041C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for COG6 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 10.7873 < 1e-12
berberine chloride 125 uM 6.56204 1.8896e-08
doxorubicin 62.5 uM 6.38184 3.5486e-08
fluconazole 130.6 uM 5.29762 1.5274e-06
thiabendazole 250 uM 5.26975 1.6802e-06
amphotericin b 0.31 uM 4.94168 5.1215e-06
itraconazole 17.7 uM 4.50499 2.1926e-05
itraconazole 17.7 uM 4.22633 5.4231e-05
tomatine 62.5 uM 4.06145 9.1761e-05
latrunculin 1.95 uM 3.51947 0.0006606

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for COG6 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
papuamide b 0.7 ug/ml 17.7432 < 1e-12
latrunculin 0.78 uM 14.6186 0.0023234
licl 100 mM 13.6014 3.2761e-11
rapamycin 9 nM 13.3019 0.0028021
bleomycin 1.13 ug/ml 12.5204 1.2701e-10
latrunculin 0.78 uM 12.1651 2.0244e-10
bleomycin 1.7 ug/ml 11.1473 8.1881e-10
synthetic complete for BY4743 0 10.9069 5.6291e-05
latrunculin 0.78 uM 10.8761 0.00083168
latrunculin 3 uM 10.8696 1.2193e-09

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YNL041C

Top 10 functional gene interactors with YNL041C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with COG6 by heterozygous co-sensitivity:

Query Interactor Correlation
COG6 CAF4 0.32528
COG6 RAV1 0.32506
COG6 CSI2 0.31322
COG6 COG5 0.31274
COG6 RFS1 0.31113
COG6 YMR085W 0.31054
COG6 MBP1 0.28907
COG6 YGR291C 0.28584
COG6 STB1 0.28343
COG6 YMR074C 0.28262

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with COG6 by homozygous co-sensitivity:

Query Interactor Correlation
COG6 COG8 0.77685
COG6 COG7 0.75168
COG6 COG5 0.61972
COG6 ARL3 0.52595
COG6 IRS4 0.5234
COG6 SYS1 0.46646
COG6 MDM20 0.45749
COG6 ARL1 0.45418
COG6 VPS52 0.44975
COG6 TLG2 0.42532

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:




External information about YNL041C

Other databases:

Visit YNL041C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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