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Yeast Fitness
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YMR318C / ADH6



Section 1: Phenotypes.
Gene-drug relationships for YMR318C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YMR318C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ADH6 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
caspofungin 10 nM 6.99875 4.1063e-09
lapachol 1000 uM 6.8257 7.5155e-09
latrunculin 6.25 uM 6.57304 3.2064e-06
lapachol 500 uM 6.08834 9.8912e-08
quinacrine hydrochloride 1000 uM 5.75612 3.1425e-07
acriflavinium hydrochloride 250 uM 4.41723 2.9223e-05
metergoline 250 uM 4.30058 4.2687e-05
aminacrine 250 uM 3.88601 0.00015914
cantharidin 250 uM 3.74367 0.032261
fluconazole 65.3 uM 3.72552 0.00026101

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ADH6 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mms 0.002 % 7.94981 0.0077285
methotrexate 250 uM 6.32673 5.3281e-07
mitomycin c 1000 uM 5.78339 8.231e-07
synthetic complete for BY4743 0 5.76229 0.014411
ph4 7.5 5.02736 4.3753e-05
cadmium chloride 7.81 uM 4.29491 6.9e-05
synthetic complete for BY4743 0 3.75173 0.016539
licl 150 mM 3.73317 0.00034536
rapamycin 9 nM 3.64659 0.033829
licl 150 mM 3.28792 0.0011756

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YMR318C

Top 10 functional gene interactors with YMR318C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ADH6 by heterozygous co-sensitivity:

Query Interactor Correlation
ADH6 ADE17 0.5068
ADH6 GRE2 0.50324
ADH6 ECM34 0.48603
ADH6 RNH1 0.48176
ADH6 ADH4 0.48165
ADH6 TDH2 0.48068
ADH6 MSH5 0.47213
ADH6 YJL055W 0.46188
ADH6 YER093C-A 0.46112
ADH6 MUC1 0.4588

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ADH6 by homozygous co-sensitivity:

Query Interactor Correlation
ADH6 YNL303W 0.7519
ADH6 YBR116C 0.71924
ADH6 GLO4 0.71831
ADH6 YHR113W 0.71662
ADH6 OPT2 0.69673
ADH6 YOR114W 0.69274
ADH6 YAR028W 0.68994
ADH6 YCR100C 0.68941
ADH6 YMR158C-A 0.68549
ADH6 CWP1 0.68112

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YMR318C

Other databases:

Visit YMR318C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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